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Dermatologic QuickFact

Childhood cancer survivors can be at risk for developing the following dermatologic late effects:

 

   ·         Dermatologic Changes

      o   Fibrosis

      o   Telangiectasias

      o   Altered Skin Pigementation

   ·         Dermatologic Toxicity

      o   Nail Dysplasia

      o   Vitiligo

      o   Scleroderma

   ·         Permanent Alopecia

   ·         Dysplastic Nevi/Skin Cancer

 

If your patient does not have a Survivor Health Plan (SHP), please refer him/her to the appropriate survivor clinic. 

 

Important factors in determining risk for dermatologic late effects:

 

    • Age at treatment
    • Type and total dose of radiation
    • Sun exposure
    • Tanning booth
    • Gorlins’ syndrome

For recommendations on how to screen for all potential late effects, please refer to The Children’s Oncology Group Long-Term Follow-Up Guidelines.

 

 

Chemotherapy

Table 1

 

Dermatologic Changes

Dermatologic Toxicity

Permanent Alopecia

Dysplastic Nevi/ Skin Cancer

Alkylating Agents

Carmustine

   BCNU

Busulfan

Lomustine

   CCNU

Chlorambucil Cyclophosphamide

   Cytoxan

Ifosphamide

Mechlorethamine

Melphalan

Procarbazine

Thiotepa

 

Dacarbazine

    DTIC

Temozolomide

 

 

 

 

Heavy Metals

Carboplatin

Cisplatin

 

 

 

 

 

Antimetabolites

Cytarabine

   Ara-C

Mercaptopurine

   6MP

Thioguanine

   6TG

Methotrexate

 

 

 

 

 

Anthracycline antibiotics

Daunorubicin

Doxorubicin

   Adriamycin

Epirubicin

Idarubicin

Mitoxantrone

Epipodophyllotoxins

 

 

 

 

 

Chemotherapy

Table 2

Dermatologic Changes

Dermatologic Toxicity

Permanent Alopecia

Dysplastic Nevi/ Skin Cancer

Anti-tumor antibiotics                

Bleomycin

Dactinomycin

 

 

 

 

Corticosteroids

Dexamethasone

   Decadron

Prednisone

 

 

 

 

 

Enzymes

Asparaginase

 

 

 

 

 

Plant alkaloids

Vincristine

Vinblastine

 

 

 

 

 

Epipodophyllotoxins

Etoposide

   VP16

Teniposide

   VM26

 

 

 

 

 

Radiation

Dermatologic Changes

Dermatologic Toxicity

Permanent Alopecia

Dysplastic Nevi/ Skin Cancer

All Radiation                            

 

 

 

X

TBI

 

 

 

X

Head/Brain

X

 

X

X

Neck

X

 

X

X

Thorax

X

 

X

X

Abdomen

X

 

X

X

Pelvis

X

 

X

X

Extremity

Epipodophyllotoxins

X

 

X

X

Hematopoetic Stem Cell Transplant

Dermatologic Changes

Dermatologic Toxicity

Permanent Alopecia

Dysplastic Nevi/ Skin Cancer

Hematopoeitic

Stem Cell Transplant

with any history

of chronic GVHD

Epipodophyllotoxins

 

X

X

 

 

Health Links- Teaching Handouts from The Children's Oncology Group  

Visit www.survivorshipguidelines.org  to find many of the Health Links translated into other languages. 

References:

Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers, and related Health Links  Version 4.0. October, 2013. www.survivorshipguidelines.org.

Source: Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta
Last Updated: 1/30/2015 4:08:21 PM
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