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Cancer Treatment 101 QuickFact

 Pediatric cancer treatment usually includes a combination of the following therapies:

  • Chemotherapy
  • Radiation
  • Surgery
  • Hematopoietic Stem Cell Transplant
  • Biological Therapy

If your patient does not have a Survivor Healthcare Plan (SHP), please refer him/her to the appropriate survivor clinic. 

 

Intensity and duration of treatment can influence childhood cancer survivors' risk for late effects.  It is important to have accurate treatment information to develop the risk profile and surveillance plan.

 

The Children's Oncology Group Long-term Follow-up Guidelines identify late effects associated with specific cancer therapy.  To utilize the guidelines the class of chemotherapy and field of radiation must be known.  

 

These tables have been created to assist healthcare providers in identifying the categories of exposure used in the QuickFact tables.

 

 

 

Chemotherapy Class

Chemotherapy – Generic Name

Chemotherapy – Brand Name/Index Term

Alkylating Agents               

 

Carmustine

Busulfan

Chlorambucil  

Cyclophosphamide                               

Ifosfamide

Lomustine

Melphalan

Procarbazine

Thiotepa

Mechlorethamine

 

BCNU

 

 

Cytoxan

 

CCNU

 

 

 

Nitrogen Mustard, Mustargen

Heavy Metals

 

Cisplatin

Carboplatin

 

CDDP, Platinol

Antimetabolites

 

Cytarabine

Mercaptopurine 

Thioguanine

Methotrexate

 

Cytosine Arabinoside, Ara-C

6MP, Purinethol  

6TG

MTX

 

Anthracycline antibiotics

 

Daunorubicin

Doxorubicin  

Epirubicin

Idarubicin

Mitoxantrone

 

 

Adriamycin, ADR

 

Idamycin

Anti-tumor antibiotics

Bleomycin

Dactinomycin

 

Actinomycin D, ACT

Corticosteroids

 

Dexamethasone  

Prednisone

 

Decadron

Enzymes

 

Asparaginase

 

L-Asparaginase

Elspar

Plant alkaloids

 

Vincristine

Vinblastine

 

Oncovin

Velban

Epipodophyllo-toxins

 

 

Etoposide

Etopophos

Teniposide

 

VP16

 

VM26

 

Radiation fields by anatomic region

Radiation treatment fields

Radiation treatment fields that include more than one anatomic region

Head/Brain                

Cranial

Orbital/Eye

Ear/Infratemporal

Nasopharylgeal

Oropharyngeal

Waldeyer’s Ring                                                      

Total Body Irradiation

Neck

Cervical (neck)

Supraclavicular

Total Body Irradiation

Mini-Mantle

Mantle

Extended Mantle/Subtotal Lymphoid Irradiation

Total Lymphoid Irradiation

Spine

Thorax

Chest (thorax)

Whole Lung

Mediastinal

Axilla

Total Body Irradiation

Mini-Mantle

Mantle

Extended Mantle/Subtotal Lymphoid Irradiation

Total Lymphoid Irradiation

Spine

Abdomen

Hepatic

Renal

Upper quadrant (right) (left)

Spleen (partial) (entire)

Paraaortic

Flank/Hemiabdomen  (if field did not extend below iliac crest)

Total Body Irradiation

Inverted Y /

Whole Abdomen

Extended Mantle/Subtotal Lymphoid Irradiation

Flank/Hemiabdomen (if field extended below iliac crest)

Total Lymphoid Irradiation

Spine

Pelvis

Pelvic

Vaginal

Prostate

Bladder

Iliac

Inguinal

Femoral

Total Body Irradiation

Inverted Y /

Whole Abdomen

Extended Mantle/Subtotal Lymphoid Irradiation

Flank/Hemiabdomen (if field extended below iliac crest)

Total Lymphoid Irradiation

Spine

Radiation treatment fields that

include more than one anatomic

region

Anatomic region(s) included in field

Mini-Mantle

Neck

Axilla

 

Mantle

Neck

Thorax

Extended Mantle/

Subtotal Lympoid Irradiation

Neck

Thorax

Abdomen

Inverted Y/Whole Abdomen

Flank/Hemiabdomen

(if field extended below iliac crest)

Abdomen

Pelvis

Total Lymphoid Irradiation

Neck

Axilla

Thorax

Abdomen

Pelvis

 

Spine

Neck

Thorax

Abdomen

Pelvis

Total Body Irradiation

Head/Brain

Neck

Thorax

Abdomen

Pelvis

Testicular

For recommendations on how to screen for all potential late effects, please refer to The Children's Oncology Group Long-Term Follow-Up Guidelines.

 

 

References:

 

 Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers, and related Health Links Version 4.0. October, 2013. www.survivorshipguidelines.org.

Source: Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta
Last Updated: 1/26/2015 9:29:53 PM
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